Search results for " nucleic acid"
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How can you harness the potential of nucleic acid therapeutics?
At Cytiva, the new team is here to support you. We can help you throughout the
development of your manufacturing workflow for oligonucleotides
and the purification of mRNA drug subs…
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Virus-like Particles as Therapeutic Moieties of the Future
Rathore
Virus-like particles (VLPs) are viral capsid shells assembled without encapsulated nucleic acid. These particles resemble native virions, are highly ordered and repetitive, and are approxi…
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Genetic Vaccine Platforms Demonstrate Their Potential
“This issue can make repeated dosing difficult, since with additional dosing, the patient’s immune system may clear the viral vector before it has an opportunity to insert the nucleic acid into a cell…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
ICH Q5B (14) recommends that, “segments of the expression construct should be analyzed using nucleic acid techniques in conjunction with other tests performed on the purified recombinant protein for a…
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Choose your Optimal Wavelength for Chromatography
…eadily available
For customers with a focus on emerging molecules, proteins, peptides and nucleic acid, ÄKTA pure™ chromatography system is flexible and intuitive, and includes the ability…
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Best Practices for Selecting a Top-Quality Cell Line
The technology selectively amplifies targets of interest including genetic alterations and nucleic acid contaminants, making them easy to identify, according to Simonyi.
Samples are partitioned…
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Microbiological Testing: Time is of the Essence
As a result, microbiological testing using rapid nucleic acid methods is allowed in the pharmacopeias, while polymerase chain reaction (PCR) methods for mycobacteria detection, which typically take on…
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Patenting Prospects for Cell-Based Therapies
A nucleic acid polymer encoding a chimeric T cell receptor, said chimeric T cell receptor comprising (a) a zeta chain portion comprising the intracellular domain of human CD3 ζ chain, (b) a costimulat…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
They are usually composed of multiple proteins that encapsulate the nucleic acid payload. Additionally, there may be empty capsids that do not contain the gene of interest but are similar in physicoch…
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A Look at the Affinity Chromatography Landscape
…t only novel protein-based biologics, but a wide range of other biomolecules, from viral vectors and nucleic acids to cells.
Beyond impurity removal for “simple” proteins
Affinity chromatogra…